John Thune: “Nothing's a guarantee. There are no layups.”

I tell all of our candidates, I'll come out for you or against you, whichever helps you the most.

Over the last two years, Senate Republicans have put up a strong record of accomplishment that’s created safer streets, more money in Americans’ pockets, and new opportunities for families and businesses to get ahead.

And I think that's going to hurt them in this election in what otherwise might be arguably a decent political environment for them, but I just — their party has really, really drifted.

They've gotten so far left that they really are out of the mainstream of where the country's at.